What is the primary use of anticholinergics in the treatment of COPD?

Anticholinergics are primarily used in the treatment of Chronic Obstructive Pulmonary Disease (COPD) for the prevention of bronchospasm. These medications work by blocking the action of acetylcholine, a neurotransmitter that can lead to bronchoconstriction—the tightening of the muscles around the airways. By inhibiting acetylcholine, anticholinergics promote bronchodilation, which helps keep the airways open and improves airflow, making it easier for patients to breathe.

This preventive action is particularly beneficial for patients with COPD, as they are often prone to bronchospasm due to airway inflammation and increased mucus production. Long-acting anticholinergics, in particular, are valuable because they provide sustained bronchodilation, helping to manage symptoms over an extended period and ultimately improving the overall quality of life for COPD patients.