Which condition is NOT typically treated with antihistamines?

Antihistamines are primarily used to alleviate symptoms caused by histamine release, which is common in allergic reactions. Conditions like allergic rhinitis, anaphylaxis, and urticaria are directly related to histamine activity. Allergic rhinitis involves symptoms such as sneezing and nasal congestion due to histamine released in response to allergens. Urticaria, or hives, is characterized by itchy welts on the skin also caused by histamine.

While asthma can have allergic components, it is primarily an inflammatory condition of the airways that is not directly treated with antihistamines. Instead, asthma management often involves bronchodilators and corticosteroids to reduce inflammation and open airways. Thus, the treatment of asthma does not typically include antihistamines, making it the correct answer in this context.